Risk factors for cytomegalovirus disease in seropositive renal transplant recipients; a single-center case-controlled study

Viviana Navarro-Rodríguez; Alvaro Herrera-Munoz; Adrián Castro; Allan Ramos-Esquivel

doi:10.15171/jnp.2017.39

J Nephropathol. 2017;6(3): 240-247.
doi: 10.15171/jnp.2017.39

PMID: 28975107
PMCID: PMC5607989
Scopus ID: 85019967364

Abstract View: 8162

PDF Download: 4119

Original Article

Risk factors for cytomegalovirus disease in seropositive renal transplant recipients; a single-center case-controlled study

Viviana Navarro-Rodríguez ¹, Alvaro Herrera-Munoz ¹, Adrián Castro ¹, Allan Ramos-Esquivel ²^*

¹ Nephrology Department, Hospital San Juan de Dios, San José, Costa Rica
² Department of Pharmacology, University of Costa Rica, San José, Costa Rica

*Corresponding Author: *Corresponding author: Allan Ramos-Esquivel, , Email: allan.ramos@ucr.ac.cr

Abstract

Background: Risk factors for cytomegalovirus (CMV) disease in renal transplant recipients
have been evaluated in industrialized countries with relatively low CMV seroprevalence.

Objectives: We aimed to determine which factors are related to this illness in a high CMV
seroprevalence country.

Patients and Methods: A case-control study was performed with data from a 5-year follow-up
of 260 kidney transplant recipients at our center. Odds ratios were calculated using the
Mantel-Haenszel method.

Results: A total of 25 cases of CMV disease occurred during the study period. Recipient age
greater than 55 years old (odds ratio: 4.95, 95% CI: 1.44–17.0) and use of thymoglobulin
(odds ratio: 4.84; 95% CI: 1.10–21.39) were the only independent predictors for CMV
disease. There was not any relationship between the previous serologic status of both donor
and receptor and the occurrence of CMV disease. We did not observe any association
between the immunosuppressive regimens and CMV disease, except for thymoglobulin.

Conclusions: Only recipient age and thymoglobulin administration were related to CMV
disease. Further studies are needed to determine if prophylactic treatment confers clinical
benefit in this subset of patients.

Keywords: Cytomegalovirus, Kidney transplantation, Mycophenolate mofetil, Thymoglobulin, Transplant

Implication for health policy/practice/research/medical education:

Cytomegalovirus (CMV) disease in Costa Rica as a high seroprevalence country is related to recipient’s age and thymoglobulin
administration.

Please cite this paper as: Navarro-Rodríguez V, Herrera-Munoz A, Castro A, Ramos-Esquivel A. Risk factors for cytomegalovirus
disease in seropositive renal transplant recipients; a single-center case-controlled study. J Nephropathol. 2017;6(3):240-245.
DOI: 10.15171/jnp.2017.39.

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Abstract View: 8163

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2024	64	63	53	53	53	39	67	42	82
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2021	91	84	93	92	109	93	114	113	98	129	110	75
2020	88	41	138	122	115	103	106	88	76	63	59	76
2019	106	114	84	127	79	65	59	102	117	111	52	60
2018	94	146	149	128	105	115	104	112	103	102	97	103
2017					352	454	105	106	103	111	101	125

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