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J Nephropathol. 2017;6(3): 248-253.
doi: 10.15171/jnp.2017.40
PMID: 28975108
PMCID: PMC5607990
Scopus ID: 85019933685
  Abstract View: 3055
  PDF Download: 1885

Original Article

Comparing the values of intact parathormone and 1– 84 PTH to predict hyperparathyroidism in hemodialysis patients

Aria Jenabi, Mosadegh Jabbari, Hossein Ziaie*

1 Nephrology ward, Rasoul Akram Medical Center, Iran University of Medical Sciences Tehran Iran
*Corresponding Author: *Corresponding author: Hossein Ziaie , , Email: ho.ziaie@yahoo.com

Abstract

Background: Secondary hyperparathyroidism (SHPT) is a common complication of chronic
kidney disease (CKD) leading high mortality and even long-term morbidity. SHPT is
manifested by elevation of parathyroid hormone (PTH) and accurate determining the
level of serum PTH is very essential for early diagnosis of SHPT secondary to CKD. It is
very important to match the values obtained for intact parathormone (iPTH) and 1– 84
PTH with the minimized measurement bias.

Objectives: The present study aimed to first determine the agreement value between the
iPTH and 1– 84 PTH measures in patients with hyperparathyroidism secondary to endstage
renal disease under chronic hemodialysis. Then, we attempted to determine the best
cutoff values for these two measurements for detecting SHPT in such patients.

Patients and Methods: This cross-sectional study was conducted on hemodialysis patients.
The value of study biomarkers including iPTH and 1– 84 PTH was assessed.

Results: A strong positive association was revealed between the two indicators of iPTH and
1-84 PTH (r = 0.800, P < 0.001). The linear association between these two parameters is
independent to baseline characteristics including gender, age, body mass index, and medical
history. Among all biochemical elements, the value of 1-84 PTH was only associated with
serum calcium level negatively (r = -0.267, P = 0.027) and alkaline phosphatase positively
(r = 0.359, P = 0.003). Considering iPTH as the reference and according to the area under
the ROC curve (AUC), 1-84 PTH had high value to predict hyperparathyroidism (AUC =
0.926, P < 0.001). The best cutoff point for 1-84 PTH to discriminate hyperparathyroidism
from normal condition was 60 yielding a sensitivity of 92.3% and a specificity of 79.1%.
Among other baseline laboratory parameters, only alkaline phosphatase had an acceptable
value for diagnosing hyperparathyroidism (AUC = 0.731, P = 0.001).

Conclusions: The measurement of both iPTH and 1-84 PTH is valuable for predicting
hyperparathyroidism secondary to CKD, but according to lower cost and comparableeffectiveness
of iPTH measurement, this assay may be comparable to 1-84 PTH to predict
this consequence.


Implication for health policy/practice/research/medical education:

The measurement of both iPTH and 1-84 PTH is valuable for predicting hyperparathyroidism secondary to CKD, but according
to lower cost and comparable-effectiveness of iPTH measurement, this assay may be comparable to 1-84 PTH to predict this
consequence.

Please cite this paper as: Jenabi A, Jabbari M, Ziaie H. Comparing the values of intact parathormone and 1– 84 PTH to predict
hyperparathyroidism in hemodialysis patients. J Nephropathol. 2017;6(3):248-253. DOI: 10.15171/jnp.2017.40.

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Submitted: 20 Nov 2016
Accepted: 25 Mar 2017
ePublished: 22 Apr 2017
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