J Nephropathol. 2017;6(3): 254-263.
doi: 10.15171/jnp.2017.41
PMID: 28975109
PMCID: PMC5607991
Scopus ID: 85019897735
  Abstract View: 4284
  PDF Download: 2815


Phytotherapy of nephrotoxicity-induced by cancer drugs: an updated review

Saeid Heidari-Soreshjani 1, Majid Asadi-Samani 2*, Qian Yang 3, Ali Saeedi-Boroujeni 4

1 Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
2 Student Research Committee, Shahrekord University of Medical Sciences, Shahrekord, Iran
3 Institute of Pharmacy and Molecular Biotechnology, University of Heidelberg, Heidelberg, Germany
4 Department of Immunology, School of Medicine, Jundishapur University of Medical Sciences, Ahvaz, Iran
*Corresponding Author: *Corresponding author: Majid Asadi-Samani, Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran; , Email: biology_2011@yahoo.com


Context: Kidney is one of the vital organs maintaining homeostasis of body and thus
dysfunction of kidney affects quality of life and health severely. Anticancer drugs,
particularly chemotherapeutic agents, cause high toxicity leading kidney dysfunction
and irreparable kidney injury. Therefore, attention has recently been paid to seeking out
alternatives such as nature-based drugs that are effective but less toxic. In this regard, this
systematic review article is to report and introduce the most important medicinal plants
and their derivatives that are used to reduce anticancer drug-induced nephrotoxicity.
Evidence Acquisitions: The word nephrotoxicity alongside the words cancer or chemotherapy
in combination with some herbal terms such as medicinal plant, plants, herbs, and extracts
were administered to search for relevant publications indexed in PubMed.

Results: According to this study, 16 medicinal plants, 12 plant-based derivatives, and three
traditional plant-based formulations were found to help control and modulate anticancer
drug-induced nephrotoxicity indices.

Conclusions: Anticancer drugs cause nephrotoxicity through activating pathways of oxidative
stress, damage-associated molecular patterns (DAMPs) production, inflammatory
processes, and cell apoptosis, while medicinal plants and their derivatives can cause
reduction in nephrotoxicity and anticancer drugs side effects via their antioxidant and
anti-inflammatory properties.

Implication for health policy/practice/research/medical education:

Nephrotoxicity is one of the most common side effects induced by anticancer drugs and severely affects the patients’ lives.
It plays a significant role in the process of cancer treatment. The findings of this review article will provide researchers and
pharmacists with keys to identification of new medicinal plants to modulate and reduce nephrotoxicity and therefore explain
routes to accelerate use of natural product drugs in healthcare system.

Please cite this paper as: Heidari-Soreshjani S, Asadi-Samani M, Yang Q, Saeedi-Boroujeni A. Phytotherapy of nephrotoxicityinduced
by cancer drugs: an updated review. J Nephropathol. 2017;6(3):254-263. DOI: 10.15171/jnp.2017.41.

First Name
Last Name
Email Address
Security code

Abstract View: 4285

Your browser does not support the canvas element.

PDF Download: 2815

Your browser does not support the canvas element.

Submitted: 09 Oct 2016
Accepted: 27 Jan 2017
ePublished: 16 Feb 2017
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)