Nephrolithiasis as a common urinary system manifestation of inflammatory bowel diseases; a clinical review and meta-analysis

Mahboube Ganji-Arjenaki; Hamid Nasri; Mahmoud Rafieian-Kopaei

doi:10.15171/jnp.2017.42

J Nephropathol. 2017;6(3): 264-269.
doi: 10.15171/jnp.2017.42

PMID: 28975110
PMCID: PMC5607992
Scopus ID: 85019859332

Abstract View: 5823

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Review

Nephrolithiasis as a common urinary system manifestation of inflammatory bowel diseases; a clinical review and meta-analysis

Mahboube Ganji-Arjenaki ¹, Hamid Nasri ², Mahmoud Rafieian-Kopaei ¹^*

¹ Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
² Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

*Corresponding Author: *Corresponding author: Prof. Mahmoud Rafieian-Kopaei, , Email: rafieian@yahoo.com

Abstract

Context: The extra-intestinal manifestations of inflammatory bowel disease (IBD) are
common and involve other organs or systems for example; urinary system.

Evidence Acquisitions: For this review, we used a variety of sources by searching through Web
of Science, PubMed, EMBASE, Scopus and directory of open access journals (DOAJ).

Results: Urinary complications may occur in up to 22% of patients and nephrolithiasis
or renal/kidney stones have been suggested to be a common manifestation of disease in
forms of uric acid, calcium phosphate or calcium oxalate. We performed a meta-analysis
on five clinical trials and reported that correlation between IBD and formation of stone in
renal system is positive and significant (Fix-effect model; CI: 95%, P <0.001, and randomeffect
model; CI: 95%, P = 0.03).

Conclusions: Based on the reports of the clinical trials, calcium oxalate is more prevalent in
Crohn’s disease (CD) than in ulcerative colitis (UC).

Keywords: Crohn’s disease, Nephrolithiasis, Inflammatory bowel disease, IBD, Kidney stone, Ulcerative colitis

Implication for health policy/practice/research/medical education:

In patients with IBD, ureteral obstruction, enterovesical fistulas, and urinary tract stones have the most prevalence. Ureteral
obstruction, enterovesical fistulas are directly related to disease process but urinary tract stones are indirectly. Extra-intestinal
urolithiasis symptoms can particularly be found in the patients with Crohn’s disease compared with UC which might be in
result of steroid dependency and/or ileal involvement of CD patients. Based on the reports of the clinical trials, calcium
oxalate is more prevalent in Crohn’s disease than in UC.

Please cite this paper as: Ganji-Arjenaki M, Nasri H, Rafieian-Kopaei M. Nephrolithiasis as a common urinary system manifestation
of inflammatory bowel diseases; a clinical review and meta-analysis. J Nephropathol. 2017;6(3):264-269. DOI: 10.15171/
jnp.2017.42.

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Abstract View: 5824

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2018	45	83	84	64	59	52	42	59	57	55	57	73
2017					37	68	63	80	86	77	84	69

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