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J Nephropathol. 2022;11(4): e17290.
doi: 10.34172/jnp.2022.17290
  Abstract View: 102
  PDF Download: 43

Study Protocol

Protocol for systematic review and meta-analysis on the effect of natural products use on blood pressure in Iran

Mohammad Azadbakht 1,2 ORCID logo, Alireza Fatahian 3 ORCID logo, Seyde Sedighe Yousefi 1,4 ORCID logo, Mahmood Moosazadeh 5 ORCID logo, Moloud Fakhri 1* ORCID logo

1 Traditional and Complementary Medicine Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Iran
2 Department of Pharmacognosy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
3 MD, Interventional Electrophysiologist, Assistant Professor of Cardiology, Cardiovascular Research Center, Mazandaran University of Medical Sciences, Sari, Iran
4 Department of Persian Medicine, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
5 Gastrointestinal Cancer Research Center, Non-communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran
*Corresponding Author: *Corresponding author: Moloud Fakhri, Email: mmfir@yahoo.com,, Email: m.fakhri@mazums.ac.ir

Abstract

Background: Today, hypertension is a significant public health problem globally, widely recognized as a major risk factor for death. Blood pressure-lowering herbal medicines and natural products have been used for centuries. The protocol aims to determine the effect of natural product use on blood pressure in Iran using data from previously published randomized controlled trials. The current protocol for a systematic review and meta-analysis is designed to determine the effect of natural product use on blood pressure in Iran.

Methods: The protocol is developed using PICO (participants, interventions, comparisons, and outcomes) items to assess the effect of natural products on blood pressure reduction in randomized clinical trials (RCTs) in Iran. Specific MESH terms will be used to search Google Scholar, PubMed, and the Cochrane Central Register for randomized controlled clinical trials, as well as national databases such as Barekat Gostar, SID, Magiran, and IranDoc. The I2 index and the Q-test will be used to examine heterogeneity in the effect sizes of individual studies. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) of RCTs will be reported per Cochrane guidelines, and all forms will be based on validated Cochrane templates.

Discussion: This protocol will detail the effects of natural products (interventions) in comparison to a placebo or other control group (comparators).

Registration: The current protocol was also registered on PROSPERO (ID: CRD42021231837, https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=231837, Date: February 18, 2021).


Implication for health policy/practice/research/medical education:

Hypertension is a significant public health problem globally, widely recognized as a major risk factor for death. Blood pressure-lowering herbal medicines and natural products have been used for centuries. This protocol aims to determine the effect of natural product used on blood pressure in Iran using data from previously published RCTs.

Please cite this paper as: Azadbakht M, Fatahian A, Yousefi SS, Moosazadeh M, Fakhri M. Protocol for systematic review and meta-analysis on the effect of natural products use on blood pressure in Iran. J Nephropathol. 2022;11(4):e17290. DOI: 10.34172/jnp.2022.17290.

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Submitted: 23 Sep 2021
Accepted: 25 May 2022
ePublished: 05 Jun 2022
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